This blog post presents evidence collected from the Nucleotide Germline Cancer Evidence Base, highlighting the association between PRF1 gene mutations and various immune-mediated disorders and malignancies.
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Germline mutations in the RUNX1 gene are associated with a rare autosomal dominant disorder known as Familial Platelet Disorder with Predisposition to Acute Myeloid Leukemia (FPD/AML).
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The ARMC5 gene codes for a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. ARM family members are observed near the nucleus and may play a role as a tumor suppressor through protein-protein interactions.
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The serine protease inhibitor Kazal type 1 (SPINK1) is a potent anti-protease present in the cytoplasm of pancreatic cells, where its primary role is to prevent the auto-digestion of the gland by inactivating the intra-pancreatic trypsin enzyme.
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One of precision medicine's objectives is to optimize drug therapy. Prescribing optimized drug...
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The FDA Adverse Event Reporting System (FAERS) is a public database containing information on adverse events and medication errors. An adverse event is any symptom ...
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With advances in technology and human understanding of physiological processes, the number of associations between medically relevant entities, like disease, genes, genomic variations, environmental factors...
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The fecal microbiome transplantation (FMT) transfers the solution of feces from a healthy donor into the gastrointestinal tract of a diseased person to restore the balance of microbiota in the recipient’s intestines and confer a health benefit.
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It is nearly impossible to design a drug molecule that only has targetted effect in all living individuals. Even commonly used over-the-counter drugs, deemed and recognized by authorities as safe, can cause undesirable effects in some "hypersensitive" individuals.
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Evidence-based medicine (EBM) is the conscientious, explicit, judicious, and reasonable use of the latest evidence in making decisions for the care of patients.
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