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By Nucleati Team

Advantages of long-read sequencing for mRNA profiling of biological systems

mRNA sequencing (mRNA-Seq) evaluates the transcriptome of disease states and biological processes. mRNA-Seq is a precise method for measuring gene expression (Eichler, 2017). Unlike small reads typically produced by next-generation transcriptome sequencing, long reads help detect full-length transcripts, gene fusions, and allele-specific expression.

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By Nucleati Team

Tools to evaluate the quality of third-generation/long-read sequencing data

Third-generation sequencing, also known as long-read sequencing, uses technologies developed by Pacific Biosciences (PacBio) and Oxford Nanopore Technologies to elucidate the sequence of a DNA molecule. Several software tools are available in the public domain to evaluate the quality of sequencing results from third-generation sequencers.

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By Nucleati Team

ARMC5 Mutations and Meningioma

The ARMC5 gene codes for a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. ARM family members are observed near the nucleus and may play a role as a tumor suppressor through protein-protein interactions. 

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By Nucleati Team

SPINK1 Gene Mutation & Pancreatic Cancer

The serine protease inhibitor Kazal type 1 (SPINK1) is a potent anti-protease present in the cytoplasm of pancreatic cells, where its primary role is to prevent the auto-digestion of the gland by inactivating the intra-pancreatic trypsin enzyme.

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By Nucleati Team

CPIC guidelines: Introduction and Role in Practicing Pharmacogenetics in Clinics

One of precision medicine's objectives is to optimize drug therapy. Prescribing optimized drug...

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By Nucleati Team

FAERS: FDA Adverse Event Reporting System

The FDA Adverse Event Reporting System (FAERS) is a public database containing information on adverse events and medication errors. An adverse event is any symptom ...

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By Nucleati team

Role of rubrics in the Determination of Association, Causation, and Classification in the Medical Field

With advances in technology and human understanding of physiological processes, the number of associations between medically relevant entities, like disease, genes, genomic variations, environmental factors...

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By Nucleati Team

Aligners for long reads produced by third-generation sequencers

The third-generation sequencing technologies have rendered some read alignment tools irrelevant but still provided the background for new tools better suited for modern sequencing technologies.

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By Nucleati team

Evidence of efficacy for fecal microbiome transplantation in gastrointestinal and other diseases

The fecal microbiome transplantation (FMT) transfers the solution of feces from a healthy donor into the gastrointestinal tract of a diseased person to restore the balance of microbiota in the recipient’s intestines and confer a health benefit.

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By Nucleati Team

Importance of Compiling Case Reports of Adverse Drug Reactions & Their Role in Precision Medicine

It is nearly impossible to design a drug molecule that only has targetted effect in all living individuals. Even commonly used over-the-counter drugs, deemed and recognized by authorities as safe, can cause undesirable effects in some "hypersensitive" individuals.

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